Characterization of the kisspeptin system in human sperm

Kisspeptin, unexplained infertility and embryo implantation

Objective The primary objective of the study was to compare baseline KP levels in females with different causes of infertility and then correlate it with the risk of failure to conceive, preclinical abortion and pregnancy after intracytoplasmic sperm injection (ICSI). MaterialsAndMethods AA longitudinal cohort study was carried out from August 2014 till May 2015 recruiting one hundred and twent...

O-14: Effect of Kisspeptin on Testicular Tissue and Accessory Sex Glands, Seminal Vesicle and Prostate, in Prepubertal Rats

Background: Hypothalamus-derived kisspeptins are critical regulators of reproduction in nearly all mammalian species including the humans. These small peptides mediate their actions through the GnRH loop system. How kisspeptins regulate gonadal maturation in sexually immature male mammals remains elusive. To address this, kisspeptin was administered as subchronic (12 days) twice daily i. p. dos...

The Effect of Cigarette Smoking on Human Sperm Creatine Kinase Activity: As An ATP Buffering System in Sperm

Kisspeptin-13 ameliorates memory impairment induced by streptozotocin in male rats via cholinergic system

Introduction: Kisspeptin-13 (KP-13) is a novel endogenous factor, increases synaptic transmission and is involved in several behavioral functions such as anxiety, locomotion, epilepsy and avoidance learning. However, the role of this peptide on cognition has not been well clarified yet. Here we studied the effect of kisspeptin-13 pretreatment on spatial learning and also interaction with cholin...

Neuroendocrine Role of Kisspeptin-Neurokinin B-Dynorphin Pathway in Male Fertility and its Correlation with Melatonin

Introduction: A subset of neurons has been recently identified in the arcuate nucleus of the hypothalamus that co-localize three neuropeptides; kisspeptin, neurokinin B, and dynorphin (KNDy). These neuropeptides have been shown to play a critical role in the central control of reproduction and the modulation of gonadotrophin releasing hormone (GnRH) secretion by endocrine, metabolic and environ...